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Progesterone is meant for the continuation of pregnancy.
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Progesterone is the natural progestagen produced by the corpus luteum during the luteal phase. It is absorbed when administered orally, but is greater than 90% metabolized during the first hepatic pass. This greatly limits the efficacy of once-daily administration and also results in unphysiologically high levels of progesterone metabolites, particularly those reduced at the 5-a position.Synthetic progestins, such as medroxyprogesterone acetate and norethindrone acetate (NETA), have been specifically designed to resist enzymatic degradation and remain active after oral administration. . Recently, a new progesterone gel formulation has been designed for vaginal use. The clinical acceptability of this product has been ehanced by the bioadhesive characteristics of its polycarbophil-based gel, which conveys controlled and sustained-released properties.
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