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Human activities such as veicles, manufacturing ,mining etc. release pollution in air which in turn leads to depletion of ozone layer
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During the last several decades, human activities have resulted in considerable reduction in the ozone layer of the atmosphere. Ozone depletion occurs when destruction of the stratospheric ozone is more than the production of the molecule.  
main ozone depletion reason..
- chloro fluorocarbons 
- methyl choloform 
- hydrochlorofluorocarbons 
- halons 
- carbontetrachloride
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