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Procedure to observe nucleus in cheek cells: →Wash your mouth and scrape a little of the internal lining of your cheek inside your mouth with a clean toothpick or spatula or ice cream spoon. →Place the scrape in a watch glass containing a very small amount of normal saline. →Then place the material on a glass slide. →Put a drop of methylene blue (stain) and wait for a couple of minutes. →Wipe off the extra stain with fine cloth or blotting paper. →Put a drop of glycerin over it. →Place a coverslip. Tap the coverslip with the blunt end of needle so as to spread the cells. Observe under microscope! ! You can observe the nucleus in cheek cells which is dark coloured spherical or oval dot in centre. Hope this helps you
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We can observe with help of microscope

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