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1. Sickle cell's anaemia:The disease is characterized by sickle shaped red blood cells, which are formed due to the mutant haemoglobin molecule. The disease is controlled by HbA and HbS allele. The homozygous individuals with genotype, HbS HbS, show the symptoms of this disease while the heterozygous individuals with genotype, HbA HbS, are not affected. However, they act as carriers of the disease. 2. Down's syndrome:It is an autosomal disorder that is caused by the trisomy of chromosome 21.
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