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 Myxedema refers to deposition of mucopolysaccharides in the dermis, which results in swelling of the affected area. One manifestation of myxedema occurring in the lower limb is pretibial myxedema, a hallmark of Graves Disease, an autoimmune form of hyperthyroidism. Myxedema can also occur in Hashimotos' thyroiditis and other long-standing forms of Hypothyrodism.
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Myxedema refers to swelling of the skin and hidden tissues displaying a slippery texture, owing to a thyroid gland which is not functioning effectively. 

Mental deficiency
Puffiness around the eyes
Huskiness of voice
Gain in weight
Lack of tolerance to cold

Thyroxin tablets
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