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When a microbe infects specific organ of an organ in
a particular type of disease OR we can say that microbe affects the same organ and organ of the same system as point of entry.
Like in case of TB the point of entry :Nose 
and the organ infected is : Lungs.

There is another type of Tissue specific manifestation in which the point of entry anf organ to be affected are entirely diffrent and unrelated means not part of single system .
Like Japanese Encephalitis in this microbe enters through blood vessels and brain is affected .
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