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As Human have eukaryotes and do not have cell walls. Actually, penicillin affects the prokaryotic cell which have cell walls.
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Overdose of penicillin affect human cells. The wall of prokaryotic cell will broke up and may results in many dangerous symptoms. Antibodies will be killed and good microbes.

But a few penicillin can't affect human cells. Because Human body produce Antibodies to fight diseases and control blood cells.
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