It has been over 20 years since the AIDS epidemic began. During this time, considerable strides have been made in understanding the life cycle of the causative agent of AIDS, the lentivirus human immunodeficiency virus (HIV). All mammalian lentiviruses infect monocytes/macrophages. HIV and simian immunodeficiency virus (SIV) are peculiar amongst the lentiviruses in that they also infect CD4 T-cells and this substantially amplifies viral production. This “peculiarity” mediates CD4 T-cell loss and immunosuppression that characterize AIDS. Because immunosuppression was the clinically defining symptom of AIDS, early studies of HIV infection focused on infection of CD4 T-cells. However, it was soon recognized that macrophage tropic strains are the predominant viruses transmitted between hosts and the principal strains associated with neurological disease 
Mitochondria is involved in producing hyv's because it is powerhouse of cell