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  • Ambitious
Progesterone is meant for the continuation of pregnancy.
Progesterone is the natural progestagen produced by the corpus luteum during the luteal phase. It is absorbed when administered orally, but is greater than 90% metabolized during the first hepatic pass. This greatly limits the efficacy of once-daily administration and also results in unphysiologically high levels of progesterone metabolites, particularly those reduced at the 5-a position.Synthetic progestins, such as medroxyprogesterone acetate and norethindrone acetate (NETA), have been specifically designed to resist enzymatic degradation and remain active after oral administration. . Recently, a new progesterone gel formulation has been designed for vaginal use. The clinical acceptability of this product has been ehanced by the bioadhesive characteristics of its polycarbophil-based gel, which conveys controlled and sustained-released properties.
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