Lysosomes are the ones which is surrounded by the membrane which contains the digestive engymes that breaks the large food globules into smple nes where as vacuoles are the storage sacs which stores the colourful pigments, undigested nutrients etc.
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1- Surrounded by membrane
2- Contains digestive engymes
3- Make simple sugar
4- Mainly found in animals cell
5-Small in size
6- Digest dead or un-functinable cell

1- Surrounded by tonoplast membrane
2- Contains colorful pigments.
3- Store water
4- Mainly found in plants cell
5- Large in size
6- Store waste products and food 
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here we are comparing so according to comparision we can write like this here.. no probs :)
i have written mainly***