Scientists are searching for it we can't give any specific reason for may be drought,epidemics o may be also earthquake or other any disaster
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There are no proper reasons which give us an idea for the decline of the harappan culture.
based on the speculations of historians the following causes may have led to the decline 
1) attack of Aryans - the destruction caused may have led to the decline 
2)climatic disaster
3) natural calamity like earthquake, flood