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The sexual stage of Plasmodium takes place in female Anopheles mosquito whereas the asexual stage occurs in man. When a female Anopheles mosquito bites an infected person, these parasites enter the mosquito and undergo further development in the body of the mosquito. The parasites multiply within the body of the mosquito to form sporozoites that are stored in the salivary glands of the mosquito. When these mosquitoes bite a healthy person, the sporozoites (the infectious stage) are introduced into his body. They multiply within the liver cells first and enter the Red Blood Cells(RBC) of man, resulting in the rupture of RBC. This results in the release of toxic substance called haemozoin which is responsible for the chill and high fever, recurring every three to four days.