The frontal lobe is one of the four major lobes of the cerebral cortex in the brain of mammals. The frontal lobe is located at the front of each cerebral hemisphere and positioned anterior to (in front of) the parietal lobe and superior and anterior to the temporal lobes. It is separated from the parietal lobe by a space between tissues called the central sulcus,
and from the temporal lobe by a deep fold called the lateral (Sylvian)
sulcus. The precentral gyrus, forming the posterior border of the
frontal lobe, contains the primary motor cortex, which controls voluntary movements of specific body parts.
The frontal lobe contains most of the dopamine-sensitive neurons in the cerebral cortex. The dopamine system is associated with reward, attention, short-term memory tasks, planning, and motivation. Dopamine tends to limit and select sensory information arriving from the thalamus to the fore-brain. A report from the National Institute of Mental Health says a gene variant that reduces dopamine activity in the prefrontal cortex
is related to poorer performance and inefficient functioning of that
brain region during working memory tasks, and to slightly increased risk