Nature Medicine is a monthly peer-reviewed medical journal publishing research articles, reviews, news and commentaries in the biomedical area, including both basic research and early-phase clinical research covering all aspects of medicine. The journal seeks to publish research papers that "demonstrate novel insight into disease processes, with direct evidence of the physiological relevance of the results" The journal was established in 1995 and is published by the Nature Publishing Group. As with other Nature journals, there is no external editorial board, with editorial decisions being made by an in-house team, although peer review by external expert referees forms a part of the review process. Its 2014 impact factor was 27.363, making it the highest-cited research journal in preclinical medicine.