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Robert Koch  isolated and characterized the bacilli of anthrax, and tuberculosis and demonstrated their causative role by a series of experiments. After identifying the tubercle bacillus, Koch has advocated his postulate, in order to distinguish a pathogenic microbe from adventitious microbes. The impact of his work towards the end of 19th century lead to the discovery of “specific toxins” made by the causative bacteria for diphtheria and tetanus and “antibodies” produced in host animals against the specific toxins. His findings led to immunization therapy. He was also awarded the Nobel prize.
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