If my databases are right, it says when we use chemicals like CFCs(chloroflurocarbons) which are light in weight and rise in the air until they reach the ozone layer and react with the O3 (ozone) forming different compounds and thus depleting the density of the ozone gases in the layer. CFCs are one of the compounds that we use in our daily lifes (refridgerators and correction pens and paints) which lead to ozone depletion.
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UV radiation and CFC are responsible for ozone depletion and these react with ozone to change it into some other subtance.And this requires a number of reactions to form