Glucogon acts mainly on the liver cells and stimulate glycogenolysis resulting in an increased blood sugar . in addition , this hormone stimulates the procees of gluconeogenesis which also contributes to hyperglycemia. Glucagon reduces the cellular glucose uptake and utilisation .Thus , glucagon is a hyperglycemic hormone
insulin act mainly on hepatocytes and adipocytes and enhances the cellular glucose uptake and utilisation . As a result there is a rapid movement of glucose from blood to hepatocytes and adipocytes resulting in decreased blood glucose level . Insulin stimulate conversion of glucose to glycogen.