When a microbe infects the specific organ of an individual in a particular type of disease,it is termed as organic specific manifestation.
       For example = In tuberculosis the microbe infects the specific organ(lungs of an individual). 
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When disease causing pathogen attacks attacts a specific organ and the disease is restricted to that organ only it is known as organ specific manifestation.
If the lungs are the targets, then symptoms will be cough and breathlessness
If the liver is targeted, there will be jaundice.
If the brain is the target, we will observe headaches, vomiting, fits or unconsciousness.
 Different species of microbes seem to have evolved to home in on different parts of the body. In part, this selection is connected to their point of entry. If they enter from the air via the nose, they are likely to go to the lungs. This is seen in the bacteria causing tuberculosis. If they enter through the mouth, they can stay in the gut lining like typhoid causing bacteria Or they can go to the liver,like the viruses that cause jaundice. But this needn.t always be the case. An infection like HIV,  that comes into the body thru the sexual organs, will spread to lymph nodes all over the body. Malaria-causing microbes, entering through a mosquito bite, will go to the liver, and then to the red blood cells. The virus causing Japanese encephalitis, or brain fever, will similarly enter through a mosquito bite. But it goes on to infect the brain.